Twelve patients were treated within 8 hours of symptom onset (range, 1½ hours to 16 days). The median National Institutes of Health Stroke Scale score at onset was 20 (range, 2-39), and the median Glasgow Coma Scale score was 9 (range, 3-15). Results Nine patients received intravenous therapy 12 patients received intra-arterial therapy. Main Outcome Measures National Institutes of Health Stroke Scale, Glasgow Coma Scale, and modified Rankin Scale scores were evaluated at baseline, and the modified Rankin Scale was measured 3 months after stroke, with a good outcome being a modified Rankin Scale score of 2 or less. Objective To determine effective thrombolytic treatment times for posterior circulation stroke and factors that might help predict clinical outcome.ĭesign We describe our experience treating 21 consecutive patients with either intravenous or intra-arterial thrombolytic therapy for posterior circulation ischemic stroke between October 9, 1993, and February 19, 2001. Consequently, there is less published information on thrombolytic therapy for posterior circulation stroke. Shared Decision Making and Communicationīackground Randomized trials of thrombolytic stroke treatment have either excluded patients with posterior circulation ischemia or used inclusion criteria making enrollment of these patients less likely. Scientific Discovery and the Future of Medicine.
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